Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions

• Main Authors: Ruohui Zheng (Author), Guru R. Valicherla (Author), Junmei Zhang (Author), Jeremy Nuttall (Author), Peter Silvera (Author), Leslie J. Marshall (Author), Philip E. Empey (Author), Lisa C. Rohan (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dapivirine (DPV) vaginal ring was developed by the nonprofit International Partnership for Microbicides (IPM) for reducing the risk of HIV infection. A clinical study (IPM 028) showed that concomitant use of the DPV ring and miconazole (MIC) altered DPV pharmacokinetic profile. In this work, we...