Mass balance and pharmacokinetic characterization of zavegepant in healthy male subjects

• Main Authors: Rajinder Bhardwaj (Author), Mary Donohue (Author), Jennifer Madonia (Author), Matt S. Anderson (Author), Kyle Matschke (Author), Richard Bertz (Author), Robert Croop (Author), Jing Liu (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Zavegepant, a high‐affinity, selective, small‐molecule calcitonin gene‐related peptide receptor antagonist, is approved as a nasal spray for acute treatment of migraine in adults. This phase I, open‐label, single‐center, single‐period, nonrandomized study in six healthy male subjects assess...