Investigation of Alogliptin-Loaded In Situ Gel Implants by 2³ Factorial Design with Glycemic Assessment in Rats

• Main Authors: Tarek M. Ibrahim (Author), Margrit M. Ayoub (Author), Hany M. El-Bassossy (Author), Hanan M. El-Nahas (Author), Eman Gomaa (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study was to design injectable long-acting poly (lactide-co-glycolide) (PLGA)-based in situ gel implants (ISGI) loaded with the anti-diabetic alogliptin. Providing sustained therapeutic exposures and improving the pharmacological responses of alogliptin were targeted for achieving red...