Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice

• Main Authors: Yumei Lai (Author), Wei Zheng (Author), Minghao Qu (Author), Christopher C. Xiao (Author), Sheng Chen (Author), Qing Yao (Author), Weiyuan Gong (Author), Chu Tao (Author), Qinnan Yan (Author), Peijun Zhang (Author), Xiaohao Wu (Author), Guozhi Xiao (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The progressive destruction of condylar cartilage is a hallmark of the temporomandibular joint (TMJ) osteoarthritis (OA); however, its mechanism is incompletely understood. Here, we show that Kindlin-2, a key focal adhesion protein, is strongly detected in cells of mandibular condylar carti...