Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review

• المؤلفون الرئيسيون: Júlia Niehues da Cruz (مؤلف), Débora Delwing Dal Magro (مؤلف), Daniela Delwing de Lima (مؤلف), José Geraldo Pereira da Cruz (مؤلف)
• التنسيق: كتاب
• منشور في: Universidade de São Paulo, 2017-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

ABSTRACT Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs...