Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway

• Main Authors: Yan Qi (Author), Hong Zou (Author), XiaoHui Zhao (Author), Joanna Kapeleris (Author), Michael Monteiro (Author), Feng Li (Author), Zhi Ping Xu (Author), Yizhen Deng (Author), Yanheng Wu (Author), Ying Tang (Author), Wenyi Gu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

K-Ras is a well-studied oncogene, and its mutation is frequently found in epithelial cancers like pancreas, lung, and colorectal cancers. Cancer cells harboring K-Ras mutations are difficult to treat due to the drug resistance and metastasis properties. Cancer stem cells (CSCs) are believed the majo...