Sustained release ivermectin-loaded solid lipid dispersion for subcutaneous delivery: in vitro and in vivo evaluation

• Main Authors: Mengmeng Lu (Author), Dan Xiong (Author), Weiwei Sun (Author), Tong Yu (Author), Zixia Hu (Author), Jiafeng Ding (Author), Yunpeng Cai (Author), Shizhuang Yang (Author), Baoliang Pan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work aimed to develop a sustained release solid dispersion of ivermectin (IVM-SD) in a lipid matrix (hydrogenated castor oil, HCO) for subcutaneous delivery. Solvent-melting technology was employed to prepare IVM-SDs using HCO. The physicochemical properties of the IVM-SDs were evaluated by sca...