Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins

• Main Authors: Yuanjin Zhang (Author), Junze Huang (Author), Shengbo Huang (Author), Jie Liu (Author), Luyao Deng (Author), Chenmeizi Liang (Author), Yuanqing Guo (Author), Bingyi Yao (Author), Xin Wang (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organic anion-transporting polypeptides 1B1 (OATP1B1) plays a crucial role in the transport of statins. However, there are too few animal models related to OATP1B1, especially humanized animal models. In this study, the human SLCO1B1 cDNA was inserted into the second exon of the rat Slco1b2 gene usi...