Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

• Main Authors: Shelly Sorrells (Author), Sara Nik (Author), Mattie Casey (Author), Rosannah C. Cameron (Author), Harold Truong (Author), Cristhian Toruno (Author), Michelle Gulfo (Author), Albert Lowe (Author), Cicely Jette (Author), Rodney A. Stewart (Author), Teresa V. Bowman (Author)
• Format: Book
• Published: The Company of Biologists, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. Th...