Downstream processing of spray-dried ASD with hypromellose acetate succinate - Roller compaction and subsequent compression into high ASD load tablets

• मुख्य लेखकों: Andreas Sauer (लेखक), Shogo Warashina (लेखक), Saurabh M Mishra (लेखक), Ilja Lesser (लेखक), Katja Kirchhöfer (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Despite wide commercial application of hypromellose acetate succinate (HPMCAS) in spray-dried amorphous solid dispersion (ASD) drug products, little information is available in the references on downstream processing of spray-dried dispersions with HPMCAS. Poor flow and high dilution factor are a ch...