Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice

• Main Authors: Antoine Rohrbach (Author), Emilie Caron (Author), Rafik Dali (Author), Maxime Brunner (Author), Roxane Pasquettaz (Author), Irina Kolotuev (Author), Federico Santoni (Author), Bernard Thorens (Author), Fanny Langlet (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in mice and their role in the regulation of energy ba...