Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential

• Main Authors: Xiangning Zhang (Author), Tingting Jin (Author), Haixia Wang (Author), Shuai Han (Author), Yongxin Liang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Morphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those with terminal cancer, require high doses of m...