(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

• Asıl Yazarlar: Marouan Rami (Yazar), Jean-Yves Winum (Yazar), Claudiu T. Supuran (Yazar), Patricia Melnyk (Yazar), Saïd Yous (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Using histamine as lead molecule, a library of (hetero)aryl substituted thiazol-2,4-yl derivatives incorporating pyridine as proton shuttling moiety were obtained and investigated as activators of human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I, II, VII and XIV. Some derivatives displayed good...