Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes

• Main Authors: Aaron R. Shoemaker (Author), Ian E. Jones (Author), Kira D. Jeffris (Author), Gina Gabrielli (Author), Alyssa G. Togliatti (Author), Rajeswari Pichika (Author), Eric Martin (Author), Evangelos Kiskinis (Author), Colin K. Franz (Author), John D. Finan (Author)
• Format: Book
• Published: The Company of Biologists, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fundamental questions about patient heterogeneity and human-specific pathophysiology currently obstruct progress towards a therapy for traumatic brain injury (TBI). Human in vitro models have the potential to address these questions. Three-dimensional spheroidal cell culture protocols for human-orig...