LRP1 in GABAergic neurons is a key link between obesity and memory function

• Main Authors: Kellen Cristina da Cruz Rodrigues (Author), Seung Chan Kim (Author), Aaron Aykut Uner (Author), Zhi-Shuai Hou (Author), Jennie Young (Author), Clara Campolim (Author), Ahmet Aydogan (Author), Brendon Chung (Author), Anthony Choi (Author), Won-Mo Yang (Author), Woojin S. Kim (Author), Vincent Prevot (Author), Barbara J. Caldarone (Author), Hyon Lee (Author), Young-Bum Kim (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, blood-brain barrier integrity, and metabolic signaling in the brain. Deficiency of LRP1 in inhibitory gamma-aminobutyric acid (GABA)ergic neurons causes severe obesity in mice. However, the impact of L...