Schistosome Sulfotransferases: Mode of Action, Expression and Localization

• Main Authors: Meghan A. Guzman (Author), Anastasia Rugel (Author), Sevan N. Alwan (Author), Reid Tarpley (Author), Alexander B. Taylor (Author), Frédéric D. Chevalier (Author), George R. Wendt (Author), James J. Collins (Author), Timothy J. C. Anderson (Author), Stanton F. McHardy (Author), Philip T. LoVerde (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (<i>SULT</i>) that was only active against <i>Schistosoma mansoni</i>. We have reengineered OXA to be effective against <i>S. haematobium</i> and <i>S. japonicum</i>. Three derivatives stan...