α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli

• Main Authors: Shangang Zhao (Author), Pegah Poursharifi (Author), Yves Mugabo (Author), Emily J. Levens (Author), Kevin Vivot (Author), Camille Attane (Author), Jose Iglesias (Author), Marie-line Peyot (Author), Erik Joly (Author), S.R. Murthy Madiraju (Author), Marc Prentki (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: α/β-Hydrolase domain-6 (ABHD6) is a newly identified monoacylglycerol (MAG) lipase. We recently reported that it negatively regulates glucose stimulated insulin secretion (GSIS) in the β cells by hydrolyzing lipolysis-derived MAG that acts as a metabolic coupling factor and signaling mole...