Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia

• Main Authors: Céline Pomié (Author), Vincent Blasco-Baque (Author), Pascale Klopp (Author), Simon Nicolas (Author), Aurélie Waget (Author), Pascale Loubières (Author), Vincent Azalbert (Author), Anthony Puel (Author), Frédéric Lopez (Author), Cédric Dray (Author), Philippe Valet (Author), Benjamin Lelouvier (Author), Florence Servant (Author), Michael Courtney (Author), Jacques Amar (Author), Rémy Burcelin (Author), Lucile Garidou (Author)
• Format: Book
• Published: Elsevier, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk. Methods: We triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the...