What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses

• Main Authors: Janina Breuer (Author), Patrick Barth (Author), Yannic Noe (Author), Lyudmila Shalamova (Author), Alexander Goesmann (Author), Friedemann Weber (Author), Oliver Rossbach (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation. Formerly, we were able to inhibit hepatitis C virus pro...