What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses

• Autors principals: Janina Breuer (Autor), Patrick Barth (Autor), Yannic Noe (Autor), Lyudmila Shalamova (Autor), Alexander Goesmann (Autor), Friedemann Weber (Autor), Oliver Rossbach (Autor)
• Format: Llibre
• Publicat: Elsevier, 2022-06-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation. Formerly, we were able to inhibit hepatitis C virus pro...