Identification of SARS-CoV-2 Main Protease Inhibitors Using Chemical Similarity Analysis Combined with Machine Learning

• Príomhchruthaitheoirí: Karina Eurídice Juárez-Mercado (Údar), Milton Abraham Gómez-Hernández (Údar), Juana Salinas-Trujano (Údar), Luis Córdova-Bahena (Údar), Clara Espitia (Údar), Sonia Mayra Pérez-Tapia (Údar), José L. Medina-Franco (Údar), Marco A. Velasco-Velázquez (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2024-02-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

SARS-CoV-2 Main Protease (Mpro) is an enzyme that cleaves viral polyproteins translated from the viral genome, which is critical for viral replication. Mpro is a target for anti-SARS-CoV-2 drug development. Herein, we performed a large-scale virtual screening by comparing multiple structural descrip...