Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells

• Main Authors: Xuan Zhang (Author), Dingding Zhang (Author), Hongmin Li (Author), Zhaojun Liu (Author), Yatong Yang (Author), Jiameng Li (Author), Lishiyuan Tang (Author), Jingli Tao (Author), Honglin Liu (Author), Ming Shen (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Numerous studies have established that the hypoxic conditions within ovarian follicles induce apoptosis in granulosa cells (GCs), a pivotal hallmark of follicular atresia. Melatonin (N-acetyl-5-methoxytryptamine, MT), a versatile antioxidant naturally present in follicular fluid, acts as a safeguard...