Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53
Abstract Background While tumor suppressor p53 functions primarily as a transcription factor in the nucleus, cellular stress can cause p53 to translocate to the mitochondria and directly trigger a rapid apoptotic response. We have previously shown that fusing p53 (or its DNA binding domain, DBD, alo...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
BMC,
2019-05-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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