Integrin-Linked Kinase Expression in Human Valve Endothelial Cells Plays a Protective Role in Calcific Aortic Valve Disease

• Main Authors: Sandra Sánchez-Esteban (Author), Mercedes Castro-Pinto (Author), Alberto Cook-Calvete (Author), Paula Reventún (Author), María Delgado-Marín (Author), Lucía Benito-Manzanaro (Author), Ignacio Hernandez (Author), José López-Menendez (Author), José Luis Zamorano (Author), Carlos Zaragoza (Author), Marta Saura (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcific aortic valve disease (CAVD) is highly prevalent during aging. CAVD initiates with endothelial dysfunction, leading to lipid accumulation, inflammation, and osteogenic transformation. Integrin-linked kinase (ILK) participates in the progression of cardiovascular diseases, such as endothelial...