Transcriptomics and metabolomics reveal changes in the regulatory mechanisms of osteosarcoma under different culture methods in vitro

• Main Authors: Sen Yang (Author), Zhi Tian (Author), Yi Feng (Author), Kun Zhang (Author), Yongchun Pan (Author), Yuan Li (Author), Zhichao Wang (Author), Wenhao Wei (Author), Xiaochen Qiao (Author), Ruhao Zhou (Author), Lei Yan (Author), Qian Li (Author), Hua Guo (Author), Jie Yuan (Author), Pengcui Li (Author), Zhi Lv (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Recently, increasing attention has been drawn to the impact of the tumor microenvironment (TME) on the occurrence and progression of malignant tumors. A variety of 3D culture techniques have been used to simulate TME in vitro. The purpose of this study was to reveal the differenc...