A Novel System for Evaluating the Inhibition Effect of Drugs on Cytochrome P450 Enzymes in vitro Based on Human-Induced Hepatocytes (hiHeps)

• Main Authors: Yan Li (Author), Ying-Yuan Lu (Author), Jun Jia (Author), Meng Fang (Author), Lin Zhao (Author), Yong Jiang (Author), Yan Shi (Author), Peng-Fei Tu (Author), Xiao-Yu Guo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 (CYP) is the most important phase I drug-metabolizing enzyme, and the effect of drugs on CYP enzymes can lead to decreased pharmacological efficacy or enhanced toxicity of drugs, but there are many deficiencies in the evaluation models of CYP enzymes in vitro. Human-induced hepatocyt...