Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer

• Main Authors: Bo Qin (Author), Qian Bai (Author), Dan Yan (Author), Fanxiang Yin (Author), Zhu Zhu (Author), Chaoyuan Xia (Author), Yang Yang (Author), Yi Zhao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 1,2,3-triazole analogues as novel fat mass and obesity-associated protein (FTO) inhibitors were synthesised in this study. Among all 1,2,3-triazoles, compound C6 exhibited the most robust inhibition of FTO with an IC50 value of 780 nM. It displayed the potent antiproliferative activity a...