Exacerbation of Multiple Sclerosis by BRAF/MEK Treatment for Malignant Melanoma: The Central Vein Sign to Distinguish Demyelinating Lesions From Metastases

• Main Authors: Christopher C. Hemond MD (Author), Rohit Bakshi MD, MA (Author), Shahamat Tauhid MD (Author), Rosila Sarrosa (Author), Madison Ryan (Author), Vineetha Kamath (Author), James Thomas MD (Author), Keith R. Edwards MD (Author)
• Format: Book
• Published: SAGE Publishing, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emergence of immunomodulators as effective cancer treatments has been an important advance in cancer therapy. The combination therapy of BRAF/MEK inhibition with or without anti-CTLA-4 treatment causes an immunostimulatory effect that has greatly reduced death from melanoma. In this article, we...