Molecular Docking and Preclinical Study of Five-Membered S,S-Palladaheterocycle as Hepatoprotective Agent

• Main Authors: Nail Salavatovich Akhmadiev (Author), Albina Midkhatovna Galimova (Author), Vnira Rakhimovna Akhmetova (Author), Veronika Radievna Khairullina (Author), Rozaliia Akramovna Galimova (Author), Eduard Feliksovich Agletdinov (Author), Askhat Gabdrahmanovich Ibragimov (Author), Valery Alekseevich Kataev (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: In order to investigate mechanisms underlying the hepatoprotective action of S,Spalladaheterocycle, inhibition of cytochromes P450 has been modeled by molecular docking of four palladaheterocycle stereoisomers to the active sites of an enzymatic oxidase system. To obtain a deeper insight in...