Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells via inhibition of sodium channels

• Main Authors: Wenfang Wu (Author), Yuan Yin (Author), Peihao Feng (Author), Gong Chen (Author), Liangyu Pan (Author), Panyang Gu (Author), Siqin Zhou (Author), Fulong Lin (Author), Siyu Ji (Author), Chunbing Zheng (Author), Meichun Deng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nav1.5 channel is crucial for the proliferation and migration of breast cancer cells. In this study, we investigated the anticancer effect of JZTX-14, a natural peptide considered an effective antagonist of Nav1.5. First, we successfully isolated and purified the 31 amino acid peptide JZTX-14 contai...