Chikungunya virus infection results in higher and persistent viral replication in aged rhesus macaques due to defects in anti-viral immunity.

• Main Authors: Ilhem Messaoudi (Author), Jennifer Vomaske (Author), Thomas Totonchy (Author), Craig N Kreklywich (Author), Kristen Haberthur (Author), Laura Springgay (Author), James D Brien (Author), Michael S Diamond (Author), Victor R Defilippis (Author), Daniel N Streblow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne Alphavirus that causes a clinical disease involving fever, myalgia, nausea and rash. The distinguishing feature of CHIKV infection is the severe debilitating poly-arthralgia that may persist for several months after viral clearance. Since its...