Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis

• Main Authors: Huimin Yan (Author), Ying Hu (Author), Antonina Akk (Author), Muhammad Farooq Rai (Author), Hua Pan (Author), Samuel A. Wickline (Author), Christine T.N. Pham (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or retard OA progression. We employ a peptide-based n...