Quality-by-Design-Driven Nanostructured Lipid Scaffold of Apixaban: Optimization, Characterization, and Pharmacokinetic Evaluation

• Autors principals: Kiran Patil (Autor), Nayan Gujarathi (Autor), Charu Sharma (Autor), Shreesh Ojha (Autor), Sameer Goyal (Autor), Yogeeta Agrawal (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2024-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Apixaban, an anticoagulant, is limited in its efficacy due to poor solubility, low bioavailability, and extensive metabolism. This study investigates the application of nanostructured lipid carriers (NLCs) to enhance the bioavailability of Apixaban. NLCs were prepared using the high-pressure homogen...