Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels

• Main Authors: Satoshi Murakami (Author), Yuka Sudo (Author), Kanako Miyano (Author), Hitomi Nishimura (Author), Motohiro Matoba (Author), Seiji Shiraishi (Author), Hiroki Konno (Author), Yasuhito Uezono (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-selective transient receptor potential vanilloid (TRPV) cation channels are activated by various insults, including exposure to heat, acidity, and the compound capsaicin, resulting in sensations of pain in the skin, visceral organs, and oral cavity. Recently, TRPV1 activation was also demonstrat...