A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.

• Main Authors: Panjaporn Chaichana (Author), Narisara Chantratita (Author), Florian Brod (Author), Sirikamon Koosakulnirand (Author), Kemajittra Jenjaroen (Author), Suchintana Chumseng (Author), Manutsanun Sumonwiriya (Author), Mary N Burtnick (Author), Paul J Brett (Author), Prapit Teparrukkul (Author), Direk Limmathurotsakul (Author), Nicholas P J Day (Author), Susanna J Dunachie (Author), T Eoin West (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 geneti...