A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis.

• मुख्य लेखकों: Panjaporn Chaichana (लेखक), Narisara Chantratita (लेखक), Florian Brod (लेखक), Sirikamon Koosakulnirand (लेखक), Kemajittra Jenjaroen (लेखक), Suchintana Chumseng (लेखक), Manutsanun Sumonwiriya (लेखक), Mary N Burtnick (लेखक), Paul J Brett (लेखक), Prapit Teparrukkul (लेखक), Direk Limmathurotsakul (लेखक), Nicholas P J Day (लेखक), Susanna J Dunachie (लेखक), T Eoin West (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 geneti...