Redox Balance in β-Thalassemia and Sickle Cell Disease: A Love and Hate Relationship

• Main Authors: Rayan Bou-Fakhredin (Author), Lucia De Franceschi (Author), Irene Motta (Author), Assaad A. Eid (Author), Ali T. Taher (Author), Maria Domenica Cappellini (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

β-thalassemia and sickle cell disease (SCD) are inherited hemoglobinopathies that result in both quantitative and qualitative variations in the β-globin chain. These in turn lead to instability in the generated hemoglobin (Hb) or to a globin chain imbalance that affects the oxidative environment bot...