Synthesis, characterization, cytotoxic screening, and density functional theory studies of new derivatives of quinazolin-4(3H)-one Schiff bases

• Main Authors: Rezvan Rezaee Nasab (Author), Farshid Hassanzadeh (Author), Ghadam Ali Khodarahmi (Author), Mahmoud Mirzaei (Author), Mahboubeh Rostami (Author), Ali Jahanian-Najaf abadi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel derivatives of quinazolinone Schiff bases were synthesized from benzoic acid starting material and evaluated for potential cytotoxic activities against the human breast adenocarcinoma (MCF-7) and the human colon adenocarcinoma (HT-29) cell lines. Compared to the reference drug, the...