Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

• Glavni autori: Yee Lian Tiong (Autor), Khuen Yen Ng (Autor), Rhun Yian Koh (Autor), Gnanajothy Ponnudurai (Autor), Soi Moi Chye (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2019-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Neuropathy is a complication that affects more than 50% of long-standing diabetic patients. One of the causes of diabetes neuropathy (DN) is the apoptosis of Schwann cells due to prolonged exposure to high glucose and build-up of oxidative stress. Melatonin is a hormone that has a known antioxidant...