Integrated serum pharmacochemistry, 16S rDNA sequencing, and metabolomics to reveal the material basis and mechanism of Shouhui Tongbian capsule against diphenoxylate-induced slow transit constipation in rats

• Main Authors: Jiaying Yang (Author), He Xiao (Author), Jingchun Yao (Author), Pin Zhang (Author), Bojiao Yi (Author), Zhengyu Fang (Author), Na Guo (Author), Yongxia Guan (Author), Guimin Zhang (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Slow transit constipation (STC) is highly prevalent and has rising incidence. Shouhui Tongbian capsule (SHTB) is a traditional Chinese Medicine formula with extensive and highly efficacious usage in STC treatment, however, its mechanism of action, especially the regulation of mic...