The Effects of a Blood-Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy

• Main Authors: Joshua Yang (Author), Weijun Ou (Author), Nataraj Jagadeesan (Author), Juste Simanauskaite (Author), Jiahong Sun (Author), Demi Castellanos (Author), David H. Cribbs (Author), Rachita K. Sumbria (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for Alzheimer's disease (AD) but has limited blood-brain barrier (BBB) permeability. EPO fused to a chimeric transferrin receptor monoclonal antibody (cTfRMAb) enters the brain via TfR-mediated transcytosis across th...