Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects

• Main Authors: Lise Verbruggen (Author), Lindsay Sprimont (Author), Eduard Bentea (Author), Pauline Janssen (Author), Azzedine Gharib (Author), Lauren Deneyer (Author), Laura De Pauw (Author), Olaya Lara (Author), Hideyo Sato (Author), Charles Nicaise (Author), Ann Massie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been performed using the EMA- and FDA-approved drug sulfasal...