Study of homogenization on media milling time in preparation of irbesartan nanosuspension and optimization using design of experiments (DoE)

• Main Authors: Chetan Borkhataria (Author), Dhavalkumar Patel (Author), Swati Bhagora (Author), Nilesh Patel (Author), Kalpesh Patel (Author), Ravi Manek (Author)
• Format: Book
• Published: SpringerOpen, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The present investigation aimed at preparing nanosuspension of irbesartan to improve its dissolution. Dissolution enhancement of irbesartan can improve the oral bioavailability. Here, it was also studied how media milling time can be reduced by subjecting irbesartan to prior homo...