Di-PEGylated insulin: A long-acting insulin conjugate with superior safety in reducing hypoglycemic events

• Main Authors: Zhipeng Zeng (Author), Runcheng Tan (Author), Shi Chen (Author), Haolin Chen (Author), Zhijia Liu (Author), Lixin Liu (Author), Mingqiang Li (Author), Yongming Chen (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes, its therapeutic potential is compromised by its short half-life and narrow therapeutic index. Current long-acting insulin analogs, such as insulin-polymer conjugates, are mainly used to improve pharmacokinetics...