Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde

• Main Authors: Rana T. Alhashimi (Author), Tarek A. Ahmed (Author), Lamya Alghanem (Author), Piyusha P. Pagare (Author), Boshi Huang (Author), Mohini S. Ghatge (Author), Abdelsattar M. Omar (Author), Osheiza Abdulmalik (Author), Yan Zhang (Author), Martin K. Safo (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthetic allosteric effector of hemoglobin, TD-7 has been investigated as a potential therapeutic agent for the treatment of sickle cell disease. The pharmacologic activity of TD-7 is due to formation of a Schiff-base interaction between its aldehyde group and the two N-terminal αVal1 amines of...