Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

• Main Authors: Sebastian Brachs (Author), Angelika F. Winkel (Author), Hui Tang (Author), Andreas L. Birkenfeld (Author), Bodo Brunner (Author), Kerstin Jahn-Hofmann (Author), Daniel Margerie (Author), Hartmut Ruetten (Author), Dieter Schmoll (Author), Joachim Spranger (Author)
• Format: Book
• Published: Elsevier, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5,...