Identification and functional analysis of Trypanosoma cruzi genes that encode proteins of the glycosylphosphatidylinositol biosynthetic pathway.

• Main Authors: Mariana S Cardoso (Author), Caroline Junqueira (Author), Ricardo C Trigueiro (Author), Hosam Shams-Eldin (Author), Cristiana S Macedo (Author), Patrícia R Araújo (Author), Dawidson A Gomes (Author), Patrícia M Martinelli (Author), Jürgen Kimmel (Author), Philipp Stahl (Author), Sebastian Niehus (Author), Ralph T Schwarz (Author), José O Previato (Author), Lucia Mendonça-Previato (Author), Ricardo T Gazzinelli (Author), Santuza M R Teixeira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Trypanosoma cruzi is a protist parasite that causes Chagas disease. Several proteins that are essential for parasite virulence and involved in host immune responses are anchored to the membrane through glycosylphosphatidylinositol (GPI) molecules. In addition, T. cruzi...