Upregulation of Peroxiredoxin-2 in Well-Differentiated Pancreatic Neuroendocrine Tumors and Its Utility as a Biomarker for Predicting the Response to Everolimus

• Main Authors: Eui Joo Kim (Author), Yoon Jae Kim (Author), Hye In Lee (Author), Seok-Hoo Jeong (Author), Hyo Jung Nam (Author), Jae Hee Cho (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Pancreatic neuroendocrine neoplasms (pNENs) account for 2-3% of pancreatic malignancies. Peroxiredoxins (Prdxs), which are major cellular antioxidants, are involved in multiple oncogenic signaling pathways. We investigated the role of peroxiredoxin-2 in QGP-1 human pNEN cell line and patient-derived...