Discovery of AI-2 Quorum Sensing Inhibitors Targeting the LsrK/HPr Protein-Protein Interaction Site by Molecular Dynamics Simulation, Virtual Screening, and Bioassay Evaluation

Quorum sensing (QS) is a cell-to-cell communication mechanism that regulates bacterial pathogenicity, biofilm formation, and antibiotic sensitivity. Among the identified quorum sensing, AI-2 QS exists in both Gram-negative and Gram-positive bacteria and is responsible for interspecies communication....

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Main Authors: Yijie Xu (Author), Chunlan Zeng (Author), Huiqi Wen (Author), Qianqian Shi (Author), Xu Zhao (Author), Qingbin Meng (Author), Xingzhou Li (Author), Junhai Xiao (Author)
Format: Book
Published: MDPI AG, 2023-05-01T00:00:00Z.
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