Minocycline intra-bacterial pharmacokinetic hysteresis as a basis for pharmacologic memory and a backbone for once-a-week pan-tuberculosis therapy

• Main Authors: Devyani Deshpande (Author), Shashikant Srivastava (Author), Jotam Garaimunashe Pasipanodya (Author), Tawanda Gumbo (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: There is need for shorter duration regimens for the treatment of tuberculosis, that can treat patients regardless of multidrug resistance status (pan-tuberculosis).Methods: We combined minocycline with tedizolid, moxifloxacin, and rifampin, in the hollow fiber system model of tuberculosi...