Pharmacokinetic Interaction of Green Rooibos Extract With Atorvastatin and Metformin in Rats

• Main Authors: Oelfah Patel (Author), Christo J.F. Muller (Author), Elizabeth Joubert (Author), Bernd Rosenkranz (Author), Malcolm J.C. Taylor (Author), Johan Louw (Author), Charles Awortwe (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting a potential for herb-drug interaction. The present study, therefore, evaluated the effects of orally administered GRT on...