Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality.

• Main Authors: Elisabeth Astrup (Author), Jeshina Janardhanan (Author), Kari Otterdal (Author), Thor Ueland (Author), John A J Prakash (Author), Tove Lekva (Author), Øystein A Strand (Author), O C Abraham (Author), Kurien Thomas (Author), Jan Kristian Damås (Author), Prasad Mathews (Author), Dilip Mathai (Author), Pål Aukrust (Author), George M Varghese (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10-20%, further knowledge of the immune response during scrub typhus is needed. The current study was aimed at comparing plasma levels...